Post Doctoral Associate

An NIH-funded postdoctoral position is available in the Ghazi lab at the University of

Pittsburgh School of Medicine to study genes at the intersection of aging, immunity and

metabolism.

Our lab investigates (i) molecular mechanisms linking lifespan to aspects of healthspan such

as immunity, and (ii) the impact of reproductive status on longevity and healthspan, using

molecular genetics, genomics, and systems approaches in C. elegans. We demonstrated that

lifespan and healthspan can be genetically uncoupled and lifespan-enhancing genes may not

inevitably improve immunity/healthspan (Amrit et al., Nature Communications, 2019, Naim et

al., Aging Cell, 2021). Our recent work has revealed a conserved role for mRNA splicing of

lipid-hydrolyzing factors during immune response and aging. The selected candidate will

work on a multi-disciplinary, collaborative project to decipher the mechanisms underlying this

discovery in C. elegans and mammalian models.

We are seeking an enthusiastic scientist with Ph. D training in aging and/or splicing biology

and/or immunity, who functions well in a lively, collaborative lab environment. Background in

model organisms will be greatly valued but is not essential.

The University of Pittsburgh is a leader in basic, translational, and clinical research in the

fields of aging, metabolism, and immunity. Pittsburgh offers an exceptional quality of life with a low

cost of living in a lovely, green city recognized for its dynamic tech, culture, and culinary

scenes.

http://www.chp.edu/CHP/ghazilab

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