Scientist 3, Peptide Therapeutics

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech, a member of the Roche Group.

We are looking for a highly skilled and motivated peptide medicinal chemist with deep expertise in computational designs to become a key member of our dynamic research team. The ideal candidate will possess a strong background in peptide chemistry and computational design, with a proven track record in drug discovery.

This position offers a unique opportunity to contribute to the development of novel peptide-based therapeutics through the application of advanced computational techniques. As an integral part of our interdisciplinary and agile research environment, you will collaborate closely with cross-functional teams in Drug Metabolism and Pharmacokinetics, Structural Biology, Computational Sciences, Pharmacology, Pharmaceutical Sciences, and Safety to advance our mission of transforming scientific discoveries into life-changing therapies.

The Opportunity:

• Design, synthesize and optimize novel peptides for therapeutic applications, focusing on potency, selectivity, stability, and drug-like properties.

• Leverage structure-activity relationships to iteratively improve peptide function and pharmacological profiles.

• Utilize computational tools to predict, model, and refine peptide structures, conformations, and properties.

• Expand the chemical and structural diversity of our peptide libraries through innovative design strategies and incorporation of non-canonical amino acids or constrained scaffolds for drug-like properties.

• Collaborate cross-functionally with various therapeutic area biologists, structural scientists, and data scientists to integrate in silico design with experimental validation.

• Analyze complex datasets, derive actionable insights, and generate clear, data-driven reports to inform project decisions and guide next steps.

• Stay abreast of emerging trends and technologies in peptide chemistry, computational design, and machine learning to continually advance our discovery efforts.

• Contribute to intellectual property and peer-reviewed publications by communicating findings and novel concepts clearly and effectively.

Who you are:

• Ph.D. in Medicinal Chemistry, Computational Chemistry, or a related scientific discipline.

• A minimum of 3 years of relevant experience, ideally in industry, applying peptide design and chemistry methods to drug discovery.

• Proven track record in structure-based and ligand-based design, with a solid understanding of SAR and peptide optimization strategies.

• Extensive experience in innovative peptide synthesis strategies, including solid-phase and solution-phase methods.

• Familiarity with a broad range of computational tools, including molecular modeling, docking, molecular dynamics (MD) simulations, and exposure to machine learning frameworks.

• Strong analytical thinking and creative problem-solving skills, with the ability to interpret complex data and generate actionable insights.

• Excellent written and verbal communication skills, with a collaborative mindset and the ability to thrive in a cross-functional team environment.

Preferred

• Experience in drug discovery and development processes is highly preferred.

Relocation benefits are available for this posting.

The expected salary range for this position based on the primary location of California is $101,400 - $188,200. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

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Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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