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Senior Director, Global Commercial Strategy - CF Pipeline Lead

Vertex Pharmaceuticals Incorporated
paid time off, 401(k)
United States, Massachusetts, Boston
50 Northern Avenue (Show on map)
Sep 09, 2025

Job Description

Vertex operates at the forefront of scientific innovation. It has seven approved medicines: five that treat the underlying cause of cystic fibrosis ("CF"), a life-threatening genetic disease, one that treats severe sickle cell disease ("SCD") and transfusion dependent beta thalassemia ("TDT"), and one that treats moderate-to-severe acute pain. Our clinical-stage pipeline includes programs in CF, SCD, beta thalassemia, acute and peripheral neuropathic pain, APOL1-mediated kidney disease, IgA nephropathy and other autoimmune renal diseases and cytopenias, type 1 diabetes, muscular dystrophy, and autosomal dominant polycystic kidney disease.

General Summary:

The Senior Director, Global Commercial Strategy CF Pipeline Lead is accountable for understanding the evolving needs of the CF Community and Vertex's position within a potentially competitive market, actively contributing to defining the pipeline strategy, pipeline performance goals, and tracking performance against those goals.

Key Duties and Responsibilities:

  • Develops the pipeline strategy (e.g., Next Generation 3.0 and mRNA therapies) and oversees creation of brand strategies and lifecycle activities including data generation to support differentiation and commercialization goals.
  • Oversees development and implementation of strategic and tactical plans for our next generation CFTR modulators and mRNA therapies
  • Identifies the commercial opportunity for further serial innovation
  • Leads team through challenges related to creating external (promotional) communication materials for external use with customers
  • Provides input into forecasting assumptions and evaluates ROI for activities across the pipeline
  • Generates and consolidates key insights across HCPs and patient stakeholders (through market research, ad boards, etc.)
  • Leads the development of brand name for Next Generation 3.0 and VX 522.
  • Leads the development of strong collaborative partnerships with cross-functional team to support business goals
  • May lead complex projects that are cross-functional in nature

Knowledge and Skills:

  • Experience defining the strategy for pipeline products in an evolving landscape
  • Ability to oversee generation of insights, and apply those insights to business problems/opportunities
  • Analytical mindset, with demonstrated ability to develop strategy, make strategic recommendations, monitor performance, understand ROI and allocate resources
  • Exceptional working knowledge of market forecasts and relationship of business drivers to revenue
  • Exceptional working knowledge of MS Office applications, including PPT, Excel and Word
  • Experience in pharmaceutical marketing, or closely related field(s) (e.g., pharmaceutical sales, ad agency, etc.)

Education and Experience:

  • Bachelor's degree in marketing, business, or scientific degree
  • Typically requires 12 years of experience or the equivalent combination of education and experience

Pay Range:

$225,600 - $338,400

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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