Research Scientist - Cardiology

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Position Summary:

We have an exciting opportunity to join our team as a Research Scientist.

Responsible for collaborating with Principal Investigators (PI) and working independently within the scientific framework of the PI's laboratory. This role will oversee the mouse colony and support day-to-day lab operations in a cardiovascular immunology research environment. The lab focuses on atherosclerosis, immunology, and mechanisms of cardiovascular disease (CVD) using genetically modified mouse models and human samples. This position will also manage complex mouse breeding schemes, coordinate animal use for experiments, and act as an informal/acting lab manager responsible for operations, compliance, and training.

Job Responsibilities:

Mouse Colony Management

• Design, implement, and maintain complex mouse breeding strategies for atherosclerosis and immunology studies (e.g., Apoe-/-, Ldlr-/-, conditional and transgenic strains).
• Perform mouse husbandry, including weaning, sexing, identification, genotyping, and colony record-keeping.
• Plan and manage colony size and timed matings to meet experimental needs efficiently.
• Coordinate with the institutional animal facility and veterinary staff to ensure high standards of animal care and welfare.
• Maintain accurate, up-to-date digital records of breeding, lineages, health status, and assignments to experiments.

Genotyping & Phenotyping

• Perform DNA extraction, PCR, and gel electrophoresis for routine and complex genotyping.
• Analyze and document genotyping results; allocate animals to breeding or experimental cohorts.
• Assist with phenotypic characterization relevant to atherosclerosis and CVD (e.g., basic clinical scoring and tissue collection according to protocols).

Cardiovascular Tissue Collection & Processing

• Perform tissue dissection and collection, with emphasis on:
  • Harvesting whole aortas and aortic roots from murine models of atherosclerosis.
  • Isolating additional cardiovascular and immune-related tissues (e.g., heart, spleen, lymph nodes, bone marrow).
• Process tissues for histological and immunohistochemical analysis, including:
  • Embedding (e.g., OCT or paraffin) and cryosectioning/sectioning of aortic roots and other vascular tissues.
  • Preparing slides for staining (e.g., Oil Red O, H&E, Massons trichrome, immunostaining for immune and vascular markers).
• Collaborate with lab members to quantify lesion area and composition and to integrate histological data with molecular and immunological readouts.

Lab Management & Operations

• Serve as the primary point person for daily lab operations and general lab organization.
• Oversee ordering, inventory, and maintenance of equipment, reagents, and consumables.
• Develop, maintain, and enforce standard operating procedures (SOPs) for animal work, tissue processing, biosafety, and general lab practices.
• Coordinate compliance with institutional and regulatory requirements, including IACUC and biosafety protocols and mandatory trainings.
• Interface with departmental administration, core facilities, and vendors to support efficient lab functioning.

Research & Technical Support

• Support ongoing atherosclerosis and CVD projects through molecular, cellular, and histological techniques, such as:
  • qPCR, Western blotting, ELISAs.
  • Flow cytometry on immune cells (e.g., from blood, spleen, lymph nodes, bone marrow, aortas).
  • Immunofluorescence and immunohistochemistry on aortic root and vascular sections.
• Participate in experimental design discussions, particularly regarding mouse models, endpoints, and tissue collection strategies.
• Assist with data acquisition, organization, and basic analysis; contribute to figures and methods for manuscripts, presentations, and grant applications.

Training & Mentorship

• Train and supervise students, postdoctoral fellows, and research staff in:
  • Mouse handling, breeding, and colony management.
  • Cardiovascular tissue harvesting and aortic root sectioning.
  • Relevant molecular and histological techniques.
• Promote a culture of rigor, reproducibility, safety, and collaboration.

Minimum Qualifications:
To qualify you must have a MS degree and 2-4 years of experience or equivalent combination of education and experience.

Preferred Qualifications:

PhD in Biology, Molecular Biology, Immunology, Cardiovascular Biology, or a closely related field.
Experience with mouse models of atherosclerosis and CVD (e.g., Apoe-/-, Ldlr-/-, bone marrow transplantation models, conditional knockouts).
Demonstrated expertise in dissection and sectioning of aortic roots and other vascular tissues is a plus.
Prior experience acting as a lab manager, senior technician, or senior research scientist.
Proficiency with colony management software (e.g., SoftMouse, mLIMS, or equivalent).
Experience with cardiovascular and immunology techniques, such as flow cytometry, immunostaining, and analysis of immune cell populations.
Strong written and verbal communication skills and experience training/mentoring junior personnel.
Demonstrated proficiency in genotyping (PCR and gel electrophoresis) and meticulous record-keeping for mouse colonies.
Experience with tissue collection and processing, ideally including cardiovascular tissues.
Strong organizational skills, attention to detail, and ability to manage multiple concurrent tasks and deadlines.
Familiarity with institutional animal care regulations, IACUC protocols, and standard laboratory safety practices.

Qualified candidates must be able to effectively communicate with all levels of the organization.

NYU Grossman School of Medicine provides its staff with far more than just a place to work. Rather, we are an institution you can be proud of, an institution where you'll feel good about devoting your time and your talents. At NYU Langone Health, we are committed to supporting our workforce and their loved ones with a comprehensive benefits and wellness package. Our offerings provide a robust support system for any stage of life, whether it's developing your career, starting a family, or saving for retirement. The support employees receive goes beyond a standard benefit offering, where employees have access to financial security benefits, a generous time-off program and employee resources groups for peer support. Additionally, all employees have access to our holistic employee wellness program, which focuses on seven key areas of well-being: physical, mental, nutritional, sleep, social, financial, and preventive care. The benefits and wellness package is designed to allow you to focus on what truly matters. Join us and experience the extensive resources and services designed to enhance your overall quality of life for you and your family.

NYU Grossman School of Medicine is an equal opportunity employer and committed to inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration. We require applications to be completed online.

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NYU Langone Health provides a salary range to comply with the New York state Law on Salary Transparency in Job Advertisements. The salary range for the role is $58,500.00 - $73,364.20 Annually. Actual salaries depend on a variety of factors, including experience, specialty, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

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